I was studying for my upcoming board exam and came across a question on drug induced urinary calculi. I didn’t know ephedrine (+ or – guaifenesin) could cause ephedrine based stones. Pretty interesting!
As a review, here are some drugs that can cause kidney stones:
1) Indinavir, a protease inhibitor used to treat HIV infections, causes stones.
2) Magnesium Trisilicate, an antacid used to treat gastroesophageal reflux
3) Triamterene, a potassium sparing diuretic used to treat edema and hypertension
4) Ephedrine, when used alone or in combination with guaifenesin, induce calculi containing either ephedrine, or both ephedrine and guaifenesin.
5) Loop diuretics (Furosemide, Lasix), it is noteworthy that up to two thirds of low-birth-weight infants who have received furosemide therapy will develop precipitation of calcium crystals
6) Carbonic anhydrase inhibitors, drugs such as acetazolamide (Diamox), used to treat glaucoma, altitude sickness, and epilepsy, and
7) Topiramate (Topamax), an anticonvulsant medication used to treat refractory seizures, can produce severe hypocitraturia and high urinary pH, and will induce calcium phosphate calculi in up to 2% of patients on long-term therapy.
8) Zonisamide (Zonegran), a sulfonamide anticonvulsant will result in the formation of calcium phosphate calculi in 4% of the patients on this mediation.
9) Potential laxative abuse should be considered when ammonium acid urate calculi are found in the absence of UTI or bowl disease. Carbamazepine (Tegretol) used to treat seizure disorders, nerve pain and bipolar disorder is not known to be associated with urolithiasis.
Thank you AUA SASP!